Ebola virus genome sequencing data published
News > Postgraduate Study | Posted: September 24, 2014 10:55:36am GMT
An international team of researchers have published genome sequencing data to help the international efforts now underway to control the Ebola outbreak. They have noted rapid mutations that could affect current diagnostics, vaccines and therapies, and say it is imperative to monitor the viral changes and adaption.
The work published in Science was conducted by researchers in Nigeria, Scotland, Sierra Leone and the United States. The team sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone and observed a rapid increase in genetic variation. They believe the West African variant likely diverged from central African lineages around 2004 and crossed from Guinea to Sierra Leone in May 2014.
One of the authors is TDR alumni Christian Happi, a Cameroonian scientist profiled this month for his work on malaria and Lassa fever. It was in Happi’s laboratory at Redeemer’s University in Ogun State, Nigeria, where the first case of Ebola from Nigeria was diagnosed. Since then, they have been busy testing up to 20 samples a day that come in from all around Nigeria.
Tragically, five co-authors in Sierra Leone contracted Ebola and lost their battle with the disease before the manuscript was published: